Gathatoulie

And of these shall I speak to those eager, That quality of wisdom that all the wise wish And call creative qualities And good creation of the mind The all-powerful truth Truly and that more & better ways are discovered Towards perfection --Zarathustra.

Sunday, November 20, 2011

apomorphine reconsidered

The classic D1/D2 receptor agonist apomorphine has been
used as a centrally acting emetic in Parkinson treatment
and to treat erectile dysfunction. A new sublingual form
of apomorphine has recently been developed, which produces
fewer side effects, such as nausea and vomiting. It has
been assumed that apomorphine would primarily influence
erectile function by acting on oxytocinergic neurons
located in the paraventricular nucleus of the
hypothalamus. However, animal studies as well as
observations in humans have shown that motivational
aspects of sexual behavior are influenced by apomorphine
administration as well. Summarizing a series of animal
studies, we may conclude that dopamine is involved in the
appetitive phase of sexual behavior, which is primarily
processed by the nucleus accumbens, whereas consummatory
aspects of sexual performance are controlled in the dorsal
striatum. -- http://66.199.228.237/boundary/Sexual_Addiction/orgasm_dopamine.pdf

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